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Physical model of the sequence-to-function map of proteins

Tsvi Tlusty, Albert Libchaber, Jean-Pierre Eckmann

10/8/16 Published in : Phys. Rev. X 7, 021037

We treat proteins as amorphous learning matter: A `gene' encodes bonds in an `amino acid' network making a `protein'. The gene is evolved until the network forms a shear band across the protein, which allows for long-range soft modes required for protein function. The evolution projects the high-dimensional sequence space onto a low-dimensional space of mechanical modes, in accord with the observed dimensional reduction between genotype and phenotype of proteins. Spectral analysis shows correspondence between localization around the shear band of both mechanical modes and sequence ripples.

Entire article ArXiv

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  • Quantum Systems
  • Field Theory
  • Statistical Mechanics

Localization techniques in quantum field theories

Real algebraic knots and links of small degree

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